Table 4 association between single SNPs and MM risk.

From: Genetic polymorphisms associated with telomere length and risk of developing myeloproliferative neoplasms

SNP

Gene

Allele

MAF

Allelic modela

Codominant modelb

M/m

OR

95% CI

PValue

ORHet

95% CI

PValue

ORHom

95% CI

PValue

rs412658

ZNF676

C/T

0.35

1.07

0.89–1.28

0.497

1.16

0.88–1.51

0.290

1.07

0.71–1.59

0.746

rs8105767

ZNF208

A/G

0.28

1.09

0.90–1.32

0.380

0.97

0.74–1.25

0.797

1.41

0.90–2.20

0.136

rs3027234

CTC1

C/T

0.22

1.01

0.83–1.24

0.906

1.18

0.91–1.52

0.207

0.69

0.38–1.24

0.220

rs9420907

OBFC1

A/C

0.13

1.43

1.15–1.77

1.35 × 10−3

1.32

0.99–1.75

0.053

2.42

1.33–4.38

3.62 × 10−3

rs755017

ZBTB46

A/G

0.12

0.86

0.64–1.14

0.291

0.77

0.55–1.06

0.103

1.73

0.54–5.57

0.356

rs6028466

DHX35

G/A

0.07

1.12

0.81–1.53

0.495

1.18

0.83–1.67

0.366

0.81

0.19–3.48

0.776

rs7675998

NAF1

G/A

0.24

1.05

0.86–1.28

0.645

1.04

0.81–1.33

0.787

1.13

0.66–1.95

0.653

rs10936599

TERC

C/T

0.24

1.1

0.89–1.35

0.380

1.14

0.88–1.47

0.316

1.08

0.61–1.94

0.786

rs11125529

ACYP2

C/A

0.11

0.89

0.67–1.16

0.374

0.94

0.70–1.26

0.693

0.45

0.13–1.56

0.209

rs6772228

PXK

T/A

0.04

1.64

0.97–2.70

0.063

1.56

0.92–2.63

0.099

–

–

–

rs2736100

TERT

A/C

0.5

1.33

1.12–1.59

1.49 × 10−3

1.69

1.27–2.22

2.89 × 10−4

1.67

1.18–2.38

4.21 × 10−3

  1. Results in bold are statistically significant.
  2. MAF minor allele frequency, OR odds ratio, 95% CI 95% coefficient interval.
  3. aAllelic model: M vs m, common allele vs rare allele.
  4. bCodominant model: Mm vs MM, heterozygous vs common homozygous; mm vs MM, rare homozygous vs common homozygous.
  5. cDominant model: mm vs Mm + MM, rare homozygous vs heterozygous + common homozygous.
  6. dRecessive model: mm + Mm vs MM, rare homozygous + heterozygous vs common homozygous.
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