Fig. 1: Kaplan–Meier survival curves of 79 JAK2-mutated PMF patients.

a OS stratified by JAK2 allele burden. Patients with lower JAK2 allele burden had inferior survival. b OS stratified by mutation status of ASXL1 among JAK2-mutated patients. Patients with concurrent ASXL1 mutation had inferior survival. c OS stratified by combined JAK2 allele burden and ASXL1 mutation status. Patients with concurrent ASXL1 mutation and low JAK2 allele burden had distinctively inferior survival.