Table 3 Receiver operating characteristic (ROC) curves with area under the curve (AUC) analysis to identify optimal cut-offs for continuous risk factors (identified from Table 2) with respect to progression to MM within 2 years.
From: International Myeloma Working Group risk stratification model for smoldering multiple myeloma (SMM)
Cut point | Specificity (%) | Sensitivity (%) | |
|---|---|---|---|
Age (per 10 years) | 57 | 28 | 80.6 |
Hemoglobin (g/dL) | 13.3 | 39.9 | 73.3 |
Creatinine (mg/dL) | 0.81 | 42.9 | 66 |
Albumin (g/dL) | 4.09 | 46.4 | 64 |
Serum M-protein (g/dL) | 1.91 | 60 | 70.6 |
Beta-2 microglobulin (mg/dL) | 2.57 | 65.7 | 52.8 |
Absolute difference Kappa-Lambda (mg/dL), per 100 | 18.5 | 66 | 54.6 |
Involved to uninvolved sFLC ratio, per 100 | 19.3 | 78.7 | 54.7 |
Urine M-spike (mg/24 h), per 1000 | 75 | 83.1 | 29.8 |
BMPC, higher of biopsy and aspirate % | 16.4 | 58.1 | 71.8 |
