Table 4 Logistic regression equation to develop the risk score predicting progression risk at 2 years.
From: International Myeloma Working Group risk stratification model for smoldering multiple myeloma (SMM)
Risk factor | Coefficient | Odds ratio (95% CI) | p value | Score |
|---|---|---|---|---|
FLC IU | ||||
0–10 (reference) | – | – | – | 0 |
>10–25 | 0.69 | 1.99 (1.15, 3.45) | 0.014 | 2 |
>25–40 | 0.96 | 2.61 (1.36, 4.99) | 0.004 | 3 |
>40 | 1.56 | 4.73 (2.88, 7.77) | <0.0001 | 5 |
M-protein | ||||
0–1.5 (reference) | – | – | – | 0 |
>1.5–3 | 0.95 | 2.59 (1.56, 4.31) | 0.0002 | 3 |
>3 | 1.3 | 3.65 (2.02, 6.61) | <0.0001 | 4 |
BMPC | ||||
0–15 (reference) | – | – | – | 0 |
>15–20 | 0.57 | 1.77 (1.03, 3.06) | 0.04 | 2 |
>20–30 | 1.01 | 2.74 (1.6, 4.68) | 0.0002 | 3 |
>30–40 | 1.57 | 4.82 (2.5, 9.28) | <0.0001 | 5 |
>40 | 2 | 7.42 (3.23, 17.02) | <0.0001 | 6 |
FISH abnormality | 0.83 | 2.28 (1.53, 3.42) | <0.0001 | 2 |
