Table 4 Multivariate analysis for progression-free and overall survival.

From: Comparison of next-generation sequencing (NGS) and next-generation flow (NGF) for minimal residual disease (MRD) assessment in multiple myeloma

Variable

Multivariate analysis for PFS

Multivariate analysis for OS

HR [95% CI]

p

HR [95% CI]

p

R-ISS stage

    

I or II vs. III

0.37 [0.17–0.78]

0.01

0.13 [0.05–0.38]

<0.001

MRD status (NGF)

    

Negative vs. positive

0.20 [0.09–0.45]

<0.001

0.21 [0.06–0.74]

0.02

MRD status (NGS)

    

Negative vs. positive

 

>0.05

 

>0.05

  1. Those variables with a significant impact in the univariate analysis were introduced in a multivariate Cox regression model to determine which ones were predictive for survival. Hazard ratios were calculated comparing first vs. second subgroup of each variable. Cytogenetics were included only as part of the R-ISS score.
  2. CI confidence interval, HR hazard ratio, MRD minimal residual disease, NGF next-generation flow, NGS next-generation sequencing, R-ISS revised international staging system.
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