Table 1 Patient clinical characteristics.

From: Carfilzomib-associated renal toxicity is common and unpredictable: a comprehensive analysis of 114 multiple myeloma patients

 

N = 114

Age, years, median (range)

70 (36–86)

Gender, male/female

60.5%/39.5%

Median baseline eGFR (ml/min/1.73 m2) (range)

78.42 (22.2–129)

Median baseline proteinuria (range) (g/24 h)

0.249 (0.034–8.1)

Comorbidities

 Hypertension

49 (43%)

 Diabetes mellitus

23 (20%)

 Peripheral angiopathy

21 (18%)

 Coronary heart disease

7 (6%)

MM immunoglobulin type

 κLC

70 (614%)

 λLC

39 (34.2%)

 Non-secretory

5 (4.4%)

Previous HDM/ASCT

53 (47%)

Median number of previous treatments (range)

2 (1–7)

 Bortezomib

78%

 ImiD

73%

 Anthracycline

27%

 ASCT

46.5%

Carfilzomib dose (mg/m2)

 20/27

30%

 20/36

11%

 20/56

59%

Carfilzomib-dexamethasone (Kd)

75%

Kd+ Lenalidomide (KRd)

14%

Other CFz combinations

11%

  1. IMiD immunomodulatory agent, ASCT autologous stem cell transplant.