Table 2 Multivariate Cox regression analysis with survival gene signatures for the overall survival of DLBCL patients.
Training set (n = 414) | Test set (n = 179) | Entire set (n = 593) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Gene-expression variables | No. of genes | HR | 95% CI | p-value | HR | 95% CI | p-value | HR | 95% CI | p-value |
Favorable signature 1 | 86 | 0.66 | 0.53−0.81 | <0.001 | 0.78 | 0.58−1.05 | 0.097 | 0.68 | 0.57−0.80 | <0.001 |
Favorable signature 2 | 82 | 0.49 | 0.35−0.68 | <0.001 | 0.62 | 0.36−1.06 | 0.078 | 0.53 | 0.40−0.70 | <0.001 |
Unfavorable signature 1 | 92 | 1.83 | 1.37−2.43 | <0.001 | 1.5 | 0.95−2.37 | 0.08 | 1.73 | 1.36−2.20 | <0.001 |
Unfavorable signature 2 | 72 | 2.38 | 1.64–3.45 | <0.001 | 2.26 | 1.32−3.86 | 0.003 | 2.26 | 1.68−3.03 | <0.001 |