Fig. 7: Pro-survival signaling mediated by mutated MYD88.
From: SYK is activated by mutated MYD88 and drives pro-survival signaling in MYD88 driven B-cell lymphomas
Mutated MYD88 triggers assembly of the “Myddosome” that includes activated BTK and IRAK4/IRAK1 that transactivate NFκB. Mutated MYD88 also transcriptionally upregulates and transactivates through IL-6 the SRC family member HCK, that triggers activation of BTK itself, as well as AKT, and ERK. Mutated MYD88 also activates SYK, a component of the “Myddosome” that triggers STAT3 and AKT.
