Table 1 rs9344 SNP in association with African ancestry in A and with t(11;14) in B.

From: The CCND1 c.870G risk allele is enriched in individuals of African ancestry with plasma cell dyscrasias

(A)

 

Gene

Allele

SNP genotype associations with race

p-value

Chr.

Risk

Other

GT

European

N = 238

Other

N = 537

Very African

N = 123

Total

N = 898

Overall

European vs. very African

Other vs. very African

    

Missing

4

5

3

12

   

rs9344

CCND1

G

A

AA

39 (16.7%)

81 (15.2%)

5 (4.2%)

125 (14.1%)

<0.0001

<0.0001

<0.0001

 

11q13.3

  

AG

112 (47.9%)

266 (50.0%)

35 (29.2%)

413 (46.6%)

   
    

GG

83 (35.5%)

185 (34.8%)

80 (66.7%)

348 (39.3%)

   
  

Risk allele frequency

0.59

0.60

0.81

0.63

   

(B)

 

Non-t(11;14)

(N = 637)

t(11;14)

(N = 261)

Total

(N = 898)

p-value

rs9344

   

<0.0001

 Missing

6

6

12

 

 AA

109 (87.2%)

16 (12.8%)

125 (14.1%)

 

 AG

308 (74.6%)

105 (25.4%)

413 (46.6%)

 

 GG

214 (61.5%)

134 (38.5%)

348 (39.3%)

 

 Risk allele frequency

0.58

0.73

0.63

 
  1. A Chi-squared test was used to evaluate the differences across these groups.
  2. European (<0.1% African ancestry and <30% Asian ancestry), other (not European or African), very African (≥ 80% African ancestry). Chi-squared test was used to determine the overall comparison between the three ancestral groups and also between ancestral groups 1 vs. 2, and 2 vs. 3 using pairwise comparison. Pairwise comparison difference is considered statistically significant when p < 0.025 based on Bonferroni method for multiple comparison.
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