Fig. 2: Overview of chromosomal findings. | Blood Cancer Journal

Fig. 2: Overview of chromosomal findings.

From: CREBBP and STAT6 co-mutation and 16p13 and 1p36 loss define the t(14;18)-negative diffuse variant of follicular lymphoma

Fig. 2: Overview of chromosomal findings.The alternative text for this image may have been generated using AI.

Log-R and smoothed Log-R (gold line) (a) and B-Allele frequency plots (b) across all chromosomes in a single case. Gray-shaded regions represent observed CNVs, including copy-neutral loss-of-heterozygosity (CN-LOH) of 1p (black arrowhead), gain of chromosome 2 (gray arrowhead), gain of 12q (red arrowhead), and loss of 16p (yellow arrowhead). c FISH analysis using the IGH/BCL2 dual color fusion probe demonstrating two green and two orange signals, and absence of any fused (yellow) signals that would indicate t(14;18)(q32;q21). d Recurrent CNVs (present in 4+ cases), including loss/CN-LOH of 16p13.3 and loss/CN-LOH of 1p36.3 (red arrowheads), and gain/CN-LOH of 8q24, gain of 8p22 and gain/CN-LOH of 8q (blue arrowheads).

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