Fig. 6: Clonality analysis based on CNVs and mutations. | Blood Cancer Journal

Fig. 6: Clonality analysis based on CNVs and mutations.

From: CREBBP and STAT6 co-mutation and 16p13 and 1p36 loss define the t(14;18)-negative diffuse variant of follicular lymphoma

Fig. 6: Clonality analysis based on CNVs and mutations.

a Tumor purity/cellularity, as calculated by the most dominant CNV/mutation. Cases with CREBBP and STAT6 comutations show no significant difference in tumor purity when compared with cases without. b Clonal architecture of individual CNVs and mutations represented as proportion of the tumor cells (normalized to tumor %) on the y-axis. CREBBP and STAT6 mutations are indicated as shaded circles and triangles, respectively. Other mutations are represented as black dots c Individual mutations found in the top ten recurrently mutated genes shown as a proportion of the respective tumor % on the y-axis. Error bars represent median and interquartile range. Statistical analysis of clonal dominance show statistically significant differences between clonal dominance of CREBBP vs. subclonality of STAT6, TNFRSF14, KMT2D, EZH2, and CARD11 and EP300.

Back to article page