Table 2 Recurrently detected copy number variants and mutations found in diffuse follicular lymphoma (dFL) compared with previously published studies of conventional follicular lymphoma (cFL) and marginal zone lymphoma (MZL).
Copy number loss/CN-LOH | dFL % (N)* | cFL % (N) | p value | MZL % (N) | p value |
|---|---|---|---|---|---|
1p36 | 76.4% (42/55) | 21.8% (158/724) | <0.0001 | 6.5% (47/726) | <0.0001 |
16p13 | 38.5% (10/26) | 9.1% (53/583) | <0.0001 | 7.6% (30/396) | <0.0001 |
1p36 + 16p13 | 30.8% (8/26) | 3.4% (8/233) | <0.0001 | 2.2% (4/178) | <0.0001 |
Mutation | dFL % (N) | cFL % (N) | p value | MZL % (N) | p value |
CREBBP | 87.1% (27/31) | 59.6% (374/627) | 0.0021 | 6.9% (37/534) | <0.0001 |
STAT6 | 87.1% (27/31) | 10.4% (61/528) | <0.0001 | 0.6% (2/309) | <0.0001 |
TNFRSF14 | 54.8% (17/31) | 31.1% (202/649) | 0.0094 | 3.1% (10/327) | <0.0001 |
FOXO1 | 29.0% (9/31) | 7.4% (30/331) | 0.0027 | 1.3% (4/309) | <0.0001 |
KMT2D | 48.4% (15/31) | 76.9% (464/603) | 0.0009 | 11.2% (67/597) | <0.0001 |
SOCS1 | 19.4% (6/31) | 3.0% (12/270) | 0.0056 | 1.0% (3/309) | <0.0001 |
EZH2 | 29.0% (9/31) | 19.2% (123/641) | 0.1716 | 1.5% (7/469) | <0.0001 |
CREBBP + STAT6 | 74.2% (23/31) | 7.4% (35/421) | <0.0001 | 0.6% (2/309) | <0.0001 |
CREBBP + STAT6 + TNFRSF14 | 38.7% (12/31) | 2.8% (13/421) | <0.0001 | 0.3% (1/309) | <0.0001 |
CREBBP/EP300 + KMT2D | 41.9% (13/31) | 56.0% (314/561) | 0.1402 | 2.2% (11/502) | <0.0001 |
