Table 1 Baseline characteristics.

From: Changes in patient-reported outcomes in light chain amyloidosis in the first year after diagnosis and relationship to NT-proBNP change

 

N = 59

Age, median (range)

68 (48–83)

Sex (%)

Male

34 (58)

Female

25 (42)

Race (%)

White

53 (90)

Black

5 (8)

Declined to answer

1 (2)

AL subtype (%)

Kappa

13 (22)

Lambda

46 (78)

2004 stage (%)

I

14 (24)

II

17 (29)

IIIa

18 (30)

IIIb

8 (14)

Missinga

2 (3)

2012 stage (%)

1

9 (14)

2

18 (28)

3

20 (36)

4

10 (16)

Missinga

2 (6)

Mean dFLC (SD), mg/L

215.7 (224.6)

Mean NT-proBNP (SD), pg/mL

5310.3 (8445.1)

Mean troponin T (SD), ng/mL(N = 34)

0.07 (0.09)

Mean hs troponin T (SD), ng/L (N = 23)

12.6 (44)

Cardiac (%)

39 (66)

Renal (%)

34 (58)

Number of organs (%)

1

21 (36)

2

23 (39)

≥3

15 (25)

First line treatment

Cylcophosphamide/bortezomib/dexamethasone

44 (75%)

Cyclophsphamide/ixazomib/dexamethasone

2 (3%)

Cylcophosphamide/lenalidomide/dexamethasone

1 (2%)

Bortezomib/dexamethasone

2 (3%)

Daratumumab

1 (2%)

Stem cell transplant

5 (9%)

Unknown

4 (6%)

  1. dFLC—difference between involved and uninvolved free light chains.
  2. aTwo patients had missing cardiac biomarkers prior to starting therapy.