Table 2 Changes in PROs over the first year.

From: Changes in patient-reported outcomes in light chain amyloidosis in the first year after diagnosis and relationship to NT-proBNP change

PROMIS Domain

Baseline mean (SE)

Baseline to 3 months, mean change (p-value)

3 months to 1 year, mean change (p-value)

Global Physical Health Summarya

42.5 (1.6)

−3.4 (p 0.02)

3.1 (p 0.02)

Global Mental Health Summarya

48.5 (1.2)

−3.4 (p 0.005)

1.8 (p 0.1)

Physical Functiona

39.8 (1.4)

−4.1 (p 0.002)

3.5 (p 0.02)

Ability to Participate in Social Roles and Activitiesa

47.0 (1.4)

−2.8 (p 0.04)

1.8 (p 0.2)

Fatigueb

55.5 (1.6)

3.4 (p 0.02)

−3.9 (p 0.02)

Anxietyb

55.5 (1.1)

−2.1 (p 0.04)

−1.7 (p 0.2)

Depressionb

53.4 (1.2)

−1.3 (p 0.2)

−0.4 (p 0.7)

Pain Interferenceb

51.2 (1.4)

0.5 (p 0.7)

−0.3 (p 0.8)

Sleep Disturbanceb

51.8 (1.3)

0.4 (p 0.8)

−0.7 (p 0.6)

  1. Baseline mean T-scores are shown with standard errors and average changes over time with p-values (significant p-values are in bold).
  2. aNegative change implies worsening and positive change improvement for the concept measured.
  3. bNegative change implies improvement and positive change worsening for the measured concept.
  4. Bold values indicate statistical significance p < 0.05.
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