Table 5 Stage-adjusted survival analysis with baseline PROMIS domain score.

From: Changes in patient-reported outcomes in light chain amyloidosis in the first year after diagnosis and relationship to NT-proBNP change

PROMIS domain

HR (95% CI)

p-value

Global Physical Health Summarya

0.5 (0.4–0.8)

0.001

Global Mental Health Summarya

0.6 (0.4–0.9)

0.008

Physical Functiona

0.5 (0.3–0.8)

0.004

Ability to Participate in Social Roles and Activitiesa

0.6 (0.4–0.8)

0.002

Fatigueb

1.5 (1.1–2.0)

0.01

Anxietyb

1.4 (1.0–2.0)

0.05

Depressionb

1.7 (1.2–2.5)

0.006

Pain Interferenceb

1.1 (0.9–1.4)

0.4

Sleep Disturbanceb

1.1 (0.9–1.4)

0.3

  1. The hazard ratio (HR) corresponds to every 5 unit increase in score, adjusted for Mayo Cardiac 2012 stage4. HR 1 implies high risk of 1-year mortality.
  2. aDomains where higher scores mean improvement in concept being measured.
  3. bDomains where higher scores mean worsening in concept being measured.
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