Table 6 NT-proBNP response at 12 months and PROs change between baseline and 12 months.

From: Changes in patient-reported outcomes in light chain amyloidosis in the first year after diagnosis and relationship to NT-proBNP change

PROMIS domain

Estimate (SE)

p-value

Global Physical Health Summarya

−0.85 (0.59)

0.2

Global Mental Health Summarya

−1.36 (0.45)

0.006

Physical Functiona

−1.14 (0.40)

0.01

Ability to Participate in Social Roles and Activitiesa

−0.61 (0.46)

0.2

Fatigueb

0.64 (0.71)

0.4

Anxietyb

1.05 (0.63)

0.1

Depressionb

1.39 (0.56)

0.02

Pain Interferenceb

0.09 (0.52)

0.9

Sleep Disturbanceb

1.12 (0.58)

0.06

  1. This table shows the change in PRO domains corresponding to 1000 pg/ml increase in NT-proBNP. The model is adjusted for baseline NT-proBNP (e.g. for 2 patients who start at the same NT-proBNP value, a patient with a 1000 pg/ml increase at 12 months will have 0.85 smaller change in Global Physical Health Summary score than a patient without increase).
  2. aDomains where higher scores mean improvement in concept being measured.
  3. bDomains where higher scores mean worsening in concept being measured.
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