Fig. 1: SEs landscape of patients-derived MM samples and MM cell lines.
From: Myeloma-specific superenhancers affect genes of biological and clinical relevance in myeloma
A–C Enhancer regions of ten primary MM cases (MM#1–10) (A), MM cell lines (B) and the control cells (including normal plasma cell (NPC), B-lymphoma cell lines (RAJI and Daudi), three memory B cells (MBC.D1, MBC.D2, and MBC.D3) (C). Enhancers were ranked by increasing H3K27ac signal, and enhancers above the inflection point of the curve were defined as SEs. The number of SEs was shown for each sample, and examples of SEs-associated genes found in at least five primary MM cases were also presented. D SE-associated genes of in-house primary MM samples were compared with those collected from another independent MM-SE-genes dataset10 (top) and MM cell lines (bottom). E Cell type specific SE-associated genes were presented in MM (2602), NPC (247), B-lymphoma cells (1155), and MBC (217). F MM-specific SE-genes were enriched in multiple cancer-relating signaling pathways, such as Ras and EGFR pathway. G Gene Ontology (GO) molecular functions of MM-specific SE-associated genes were associated with biological processes essential to the biology of MM.
