Table 2 Details of thrombotic events occurring in secondary erythrocytosis versus World Health Organization-defined polycythemia vera patients prior to/at diagnosis and after diagnosis.
From: Phenotypical differences and thrombosis rates in secondary erythrocytosis versus polycythemia vera
Thrombotic event | All patients (n = 102) | Secondary erythrocytosis patients (n = 36) | PV patients (n = 66) | P value |
|---|---|---|---|---|
Any thrombosis at or prior to diagnosis; n (%) | 28 (27) | 9 (25) | 19 (29) | 0.68 |
Arterial thrombosis; n (%) | 23 (23) | 7 (19) | 16 (24) | 0.58 |
Cerebrovascular | 12 (52) | 1 (14) | 11 (69) | 0.04 |
Acute coronary syndrome (MI/angina) | 5 (22) | 2 (29) | 3 (19) | |
Peripheral artery disease | 5 (22) | 3 (43) | 2 (13) | |
Splanchnic | 1 (4) | 1 (14) | 0 (0) | |
Venous thrombosis; n (%) | 6 (6) | 2 (6) | 4 (6) | 0.92 |
DVT | 4 (67) | 2 (100) | 2 (50) | 0.35 |
PE | 1 (17) | 1 (25) | ||
DVT + PE | 1 (17) | 1 (25) | ||
Timing of event prior to diagnosis in years; median (range) | 4.7 (0–46.8) | 5.1 (0.6–12.4) | 4.4 (0–46.8) | 0.82 |
Any thrombosis after diagnosis; n (%) | 9 (9) | 0 (0) | 9 (14) | 0.004 |
Arterial thrombosis after diagnosis; n (%) | 7 (7) | 0 (0) | 7 (11) | 0.01 |
Cerebrovascular | 3 (43) | 0 (0) | 3 (43) | |
Acute coronary syndrome (MI/angina) | 4 (57) | 0 (0) | 4 (57) | |
Venous thrombosis after diagnosis; n (%) | 3 (3) | 0 (0) | 3 (5) | 0.10 |
DVT | 1 (33.3) | 1 (33.3) | – | |
PE | 1 (33.3) | 1 (33.3) | ||
Ocular | 1 (33.3) | 1 (33.3) | ||
Hemoglobin at time of thrombosis after diagnosis, g/L; median (range) “N” evaluable = 9 (100%) | 140 (117–204) | – | 140 (117–204) | – |
Hematocrit at time of thrombosis after diagnosis; median (range) “N” evaluable = 9 (100%) | 42 (34–61.1) | – | 42 (34–61.1) | – |
Hematocrit > 45% at time of thrombosis after diagnosis; n (%) “N” evaluable = 9 (100%) | 3 (33.3) | – | 3 (33.3) | – |
Platelets at time of thrombosis after diagnosis, x 109/L; median (range) “N” evaluable = 9 (100%) | 280 (164–840) | – | 280 (164–840) | – |
Platelets > 450 × 109/L at time of thrombosis after diagnosis; n (%) “N” evaluable = 9 (100%) | 2 (22) | – | 2 (22) | – |
Leukocytes at time of thrombosis after diagnosis, x 109/L; median (range) “N” evaluable = 9 (100%) | 6.4 (3.8–33.9) | – | 6.4 (3.8–33.9) | – |
Leukocytes > 10 × 109/L at time of thrombosis after diagnosis; n (%) “N” evaluable = 9 (100%) | 2 (22) | – | 2 (22) | – |
