Table 1 Association data for the 13q13 association signal.
From: Germline variants at SOHLH2 influence multiple myeloma risk
Population | MM + MGUS | MM | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Cases | Controls | OR | P- value | Phet | Cases | Controls | OR | P-value | Phet | |
Discovery samples, rs200203825 | ||||||||||
Sweden | 2,338 | 11,971 | 1.35 | 1.14 × 10−3 | 2,338 | 11,967 | 1.35 | 1.14 × 10−3 | ||
Iceland | 1,542 | 313,882 | 1.40 | 1.1 × 10−4 | 598 | 237,480 | 1.15 | 3.64 × 10−1 | ||
Denmark | 940 | 91,744 | 1.51 | 8.61 × 10−5 | 940 | 91,744 | 1.51 | 8.61 × 10−5 | ||
Norway | 500 | 4,696 | 1.16 | 4.16 × 10−1 | 500 | 4,696 | 1.16 | 4.16 × 10−1 | ||
Combined discovery | 5,320 | 422,293 | 1.39 | 2.65 × 10−10 | 0.63 | 4,376 | 345,887 | 1.34 | 7.37 × 10−7 | 0.39 |
Discovery samples, rs75712673 | ||||||||||
Sweden | 2,338 | 11,971 | 1.32 | 2.79 × 10−3 | 2,338 | 11,967 | 1.32 | 2.79 × 10−3 | ||
Iceland | 1,542 | 313,882 | 1.37 | 3.79 × 10−4 | 598 | 237,480 | 1.20 | 2.14 × 10−1 | ||
Denmark | 940 | 91,744 | 1.52 | 6.05 × 10−5 | 940 | 91,744 | 1.52 | 6.05 × 10−5 | ||
Norway | 500 | 4,696 | 1.17 | 3.92 × 10−1 | 500 | 4,696 | 1.17 | 3.92 × 10−1 | ||
Combined discovery | 5,320 | 422,293 | 1.37 | 1.55 × 10−9 | 0.60 | 4,376 | 345,887 | 1.34 | 6.58 × 10−7 | 0.46 |
Follow-up samples | ||||||||||
Swedena | 473 | 3,430 | 1.26 | 1.63 × 10−1 | 473 | 3,430 | 1.26 | 1.63 × 10−1 | ||
United Kingdomb | 2,282 | 5,198 | 1.26 | 9.35 × 10−3 | 2,282 | 5,198 | 1.26 | 9.35 × 10−3 | ||
USAb | 780 | 1,857 | 1.28 | 1.03 × 10−1 | 780 | 1,857 | 1.28 | 1.03 × 10−1 | ||
Germanyb | 1,508 | 2,107 | 1.44 | 1.47 × 10−2 | 1,508 | 2,107 | 1.44 | 1.47 × 10−2 | ||
Netherlandsb | 555 | 2,669 | 1.49 | 1.26 × 10−2 | 555 | 2,669 | 1.49 | 1.26 × 10−2 | ||
Combined follow-up | 5,598 | 15,261 | 1.32 | 2.6 × 10−6 | 0.86 | 5,598 | 15,261 | 1.32 | 2.6 × 10−6 | 0.86 |
Combined (discovery + follow-up) | 10,918 | 437,554 | 1.35 | 2.2 × 10−14 | 0.64 | 9,974 | 361,148 | 1.33 | 7.9 × 10−12 | 0.86 |
