Table 1 Comparison of clinico-biological characteristics at diagnosis of RARA variants and PML-RARA-positive APL.

From: Characteristics and outcome of acute myeloid leukemia with uncommon retinoic acid receptor-alpha (RARA) fusion variants

 

RARA variants

APL

p value

Age, years (range)

47 (2–83

51.5 (14–82)

0.2

Sex F/M

5/19

15/23

0.1

Morphology M3/M3v

23/1

33/5

0.5

WBC, ×109/L (range)

11.5 × 109/L

1.58 × 109/L

0.04

Platelets, ×109/L (range)

75.5 × 109/L

25.5 × 109/L

0.0009

Fibrinogen, mg/dL (range)

176 (60–675)

121 (62–237)

0.007

FLT3-ITD (POS/NEG)

 

5/8

 

Early death

2/24

5/38

0.6

Outcome of induction (CR)

16/24

33/38

0.1

EFS, 24 months/48 months, %

54.1/34

70.3/62.9

0.2

OS, 24 months/48 months, %

72/60

86.7/82.9

0.07

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