Fig. 6: γδT-cell activation with IFN-γ expression shortening time to DMR and sustaining DMR durability. | Blood Cancer Journal

Fig. 6: γδT-cell activation with IFN-γ expression shortening time to DMR and sustaining DMR durability.

From: Activated naïve γδ T cells accelerate deep molecular response to BCR-ABL inhibitors in patients with chronic myeloid leukemia

Fig. 6: γδT-cell activation with IFN-γ expression shortening time to DMR and sustaining DMR durability.

A Patients were dichotomized to low and high naïve γδT cells IFN-γ secretion groups. The cumulative rate to reach DMR was correlated with the fraction of IFN-γ + naïve γδT cells (7.5% as the optimal cutoff, according to the receiver-operating characteristic (ROC) curve and the Youden index analyses (AUROC 0.6720; 95% CI: 0.5346–0.8095). B The cumulative rate of DMR durability was associated with the fraction of IFN-γ + naïve γδT cells > 7.5%. P-values are calculated using the cumulative incidence approach and the Mentle-Cox method.

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