Table 3 Univariate and multivariate survival models.

From: A simple additive staging system for newly diagnosed multiple myeloma

Variable

Univariate

Multivariate (FISH abnormalities only)

Multivariate (all)

OS RR (95% CI)

P value

OS RR (95% CI)

P value

OS RR (95% CI)

P value

HR IgH translocations

2.0 (1.7–2.3)

<0.001

1.6 (1.3–1.9)

<0.001

1.7 (1.3–2.1)

<0.001

t(11;14)

1.0 (0.8–1.2)

0.88

—

—

—

—

Trisomies

0.8 (0.7–0.9)

0.003

0.9 (0.7–1.0)

0.08

—

—

MYC rearrangement

1.5 (1.2–1.9)

<0.001

1.5 (1.2–1.9)

0.002

1.3 (1.0–1.8)

0.06

1q gain/amplification

1.8 (1.6–2.2)

<0.001

1.6 (1.4–2.0)

<0.001

1.4 (1.2–1.8)

<0.001

Monosomy 13

1.4 (1.2–1.6)

<0.001

1.1 (0.9–1.3)

0.20

—

—

Del(17p)/monosomy 17

2.0 (1.7–2.3)

<0.001

1.9 (1.6–2.3)

<0.001

1.6 (1.3–2.0)

<0.001

ISS III (vs. ISS I/II)

1.9 (1.7–2.2)

<0.001

—

—

1.7 (1.4–2.0)

<0.001

Elevated LDH

1.6 (1.4–1.9)

0.001

—

—

1.3 (1.1–1.7)

0.01

  1. Univariate and multivariate analysis including cytogenetic abnormalities, ISS stage and LDH.
  2. Del deletion, HR high-risk, IgH immunoglobulin heavy chain gene locus, ISS international staging system, LDH lactate dehydrogenase, OS overall survival, RR risk ratio. Bolded numbers represent P values < 0.05.
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