Table 4 Adverse reactions.
Adverse reaction | ICD (n = 57) N (%) | CD (n = 53) N (%) | ||
|---|---|---|---|---|
Any grade | Grade ≥3 | Any grade | Grade ≥3 | |
Anaemia | 44 (57.2) | 17 (29.8) | 46 (86.8) | 12 (22.6) |
Thrombocytopenia | 48 (84.2) | 26 (45.6) | 35 (66.0) | 13 (24.5) |
Neutropenia | 30 (52.6) | 17 (29.8) | 28 (52.8) | 13 (24.5) |
Diarrhoea | 31 (54.4) | 6 (10.5) | 29 (54.7) | 1 (1.9) |
Constipation | 21 (36.8) | 0 | 12 (22.6) | 0 |
Nausea | 26 (45.6) | 2 (3.5) | 22 (41.5) | 0 |
Vomiting | 15 (26.3) | 2 (3.5) | 13 (24.5) | 1 (1.9) |
Sensory neuropathy | 18 (31.6) | 3 (5.3) | 9 (17.0) | 0 |
Peripheral neuropathy | 25 (43.9) | 1 (1.8) | 17 (32.1) | 0 |
Fatigue | 41 (71.9) | 4 (7.0) | 34 (64.2) | 1 (1.9) |
Infection | 29 (50.9) | 12 (21.1) | 25 (47.2) | 7 (13.2) |
Thromboembolic event | 0 | 0 | 1 (1.9) | 0 |
Oedema/ankle swelling | 18 (31.6) | 0 | 10 (18.9) | 0 |
Dyspepsia | 7 (12.3) | 0 | 2 (3.8) | 0 |
Rash | 12 (21.1) | 0 | 7 (13.2) | 0 |
Dehydration | 5 (8.8) | 0 | 3 (5.7) | 0 |
Hypotension | 2 (3.5) | 0 | 9 (17.0) | 2 (3.8) |
Muscle weakness | 7 (12.3) | 2 (3.5) | 8 (15.1) | 1 (1.9) |
Hyperglycaemia | 1 (1.8) | 0 | 8 (15.1) | 2 (3.8) |
Bleeding | 8 (14.0) | 3 (5.3) | 5 (9.4) | 1 (1.9) |
Other | 48 (84.2) | 23 (40.4) | 43 (81.1) | 17 (32.1) |
