Table 2 Incidence rates of EMD in studies of patients with MM.
From: Extramedullary disease in multiple myeloma: a systematic literature review
Reference | No. of patients | Time period covered | Diagnostic approach | Incidence |
|---|---|---|---|---|
Montefusco et al. [26] | 2322 | 2010–2018 (across all studies) | Skeletal survey, MRI, or CT; and/or physical examination | NDMM: 0.5% |
Gagelmann et al. [28] | 3744 | 2005–2014 | NR | NDMM: 3.7% |
Deng et al. [18] | 834 | 1993–2013 | X-ray, US, CT, physical examination; histologically confirmed where possible | NDMM: 4.8% RRMM: 3.4% |
Weinstock et al. [29] | 663 | 2005–2011 | Pathological or radiological evidence of EMD at any time following the initial diagnosis of MM | RRMM: 8.3% |
Pour et al. [23] | 226 | 2005–2008 | US, CT, or MRI | RRMM: 14% |
Rasche et al. [21] | 357 | 2007–2010 | Cytology, biopsy of clinical/radiological lesions | RRMM: 6.7% |
Short et al. [30] | 174 | 2007–2011 | PET/CT, MRI | NDMM: 1.7% RRMM: 7.5% |
