Table 1 Pathological features at the time of therapy-related clonal cytopenia (t-CC).

From: Therapy-related clonal cytopenia as a precursor to therapy-related myeloid neoplasms

UPIN	Age at t-CC	Gender	Cytopenia			Cellularity	M:E ratio	Precursor quantity			Evidence of dysplasia?^a			Myeloid MFC	Final phenotype
UPIN	Age at t-CC	Gender	Hgb	WBC	Plts.	Cellularity	M:E ratio	Normo.	Myeloid	Meg.	Erythroid	Myeloid	Meg.	Myeloid MFC	Final phenotype
1012	60	M	Y	N	Y	40	1.3	↑	↓	↑	Subtle	No	Subtle	Normal	t-MN
1035	55	F	N	Y	N	70	4	Normal	Normal	↑	No	No	Subtle	Normal	No t-MN
1045	77	M	Y	N	N	80		↑	↑	↑	No	Subtle	Subtle	Normal	No t-MN
1067	57	F	Y	Y	Y	50	1.5	Normal	Normal	Normal	Normal	No, toxic changes^b	Normal	Abnormal	t-MN
1132	57	M	Y	N	Y	40	2	Normal	Normal	Normal	Subtle	No	No	Normal	t-MN
1142	45	F	N	N	Y	50	2	Normal	↑	↑	No	No	No		t-MN
1151	77	M	Y	N	N	45	2	Normal	Normal	Normal	Subtle	Subtle	Subtle	Abnormal	No t-MN
1178	78	M	Y	N	Y	20	3	Normal	Normal	Normal	No	No	Subtle	Normal	No t-MN
1193	69	M	Y	Y	N	70	8	↓	↑	↑	No	No	No	Normal	No t-MN
1204	77	M	N	Y	N	35	4	↑	↑	↑	No	Subtle	Subtle	Abnormal	No t-MN
1247	59	M	N	N	Y	90	3	↑	↑	Normal	Subtle	Subtle	No	Abnormal	No t-MN
1251	67	F	Y	Y	Y	10	3	↓	↓	↓	No	No	No		No t-MN
1255	66	M	Y	Y	Y	35	1	↑	↑	Normal	No	No	No	Normal	No t-MN
1257	50	F	N	Y	N	50	4	Normal	Normal	Normal	No	No	No	Normal	No t-MN
1266	67	F	Y	Y	N	35	3	Normal	Normal	Normal	No	No	No		No t-MN
1268	58	F	N	Y	N	50	3	Normal	Normal	Normal	No	No	No	Normal	No t-MN
1275	67	M	Y	N	N	15	4	Normal	Normal	Normal	No	No	No	Normal	No t-MN
1277	68	F	N	Y	N	30	2	Normal	Normal	Normal	Subtle	No	No	Normal	No t-MN
1724	51	F	Y	N	Y	65	2.3	Normal	↑	↑	Subtle	Normal	Subtle		t-MN
2004	72	M	Y	Y	Y	30	1	↑	↓	Normal	No	No	No	Normal	t-MN
2040	67	F	Y	Y	Y	50	1.5	Normal	Normal	Normal	No	No	Subtle	Normal	No t-MN
2042	77	M	Y	N	Y	70	2	↑	↑	↑	Subtle	No	No	Normal	No t-MN
2043	66	M	Y	N	Y	40	6	↓	↑	↓	No	Subtle	No		t-MN
2049	68	F	Y	N	N	20	0.5	↑	↓	↓	Subtle	No	No	Abnormal	No t-MN
2050	74	M	N	N	Y	50	3	↑	↑	Normal	No	No	Subtle	Normal	No t-MN
2052^c	71	M	Y	N	Y	50	1.4	Normal	Normal	Normal	No	No	No	Normal	t-MN
2053	65	M	Y	N	Y	30	1	↑	↓	Normal	No	No	No		No t-MN
2054	62	F	N	N	Y		1		Normal	Normal	Subtle	No	No	Abnormal	No t-MN
2056	69	M	Yes	No	Yes	30	0.6	↑	↓	↓	Subtle	Normal	Normal		t-MN
2057	61	F	Yes	Yes	Yes	20		↓	↓	↓	Normal	Normal	Normal		t-MN
2077	70	M	Yes	Yes	Yes	20	1.1	↓	↓	↓	Normal	Normal	Normal		No t-MN
2078	83	F	No	Yes	No	20	0.3	↑	↓	Normal	Subtle	Subtle	Normal		No t-MN
2079	78	M	No	No	Yes	60	4.0	Normal	↑	Normal	Normal	Subtle	Normal		No t-MN

UPIN unique patient identification number, Hgb hemoglobin, WBC white blood count, Plts platelets, cellularity percent bone marrow cellularity, M:E myeloid to erythroid ratio, Normo. normoblasts, Meg. megakaryocytes, MFC multiparametric flow cytometry, t-MN therapy-related myeloid neoplasm. ↑ - increased, ↓ - decreased.
^aMorphological findings were nondiagnostic of myeloid neoplasm in all cases.
^bLeft-shifted maturation with toxic changes in the setting of an intraabdominal infection and recent G-CSF.
^cNGS performed using peripheral blood.

Back to article page

Table 1 Pathological features at the time of therapy-related clonal cytopenia (t-CC).

Search

Quick links