Table 2 Cox proportional hazards model for time to neutrophil recovery in lymphoma cohort.

From: Effect of granulocyte colony-stimulating factor on toxicities after CAR T cell therapy for lymphoma and myeloma

Variable

Univariate analysisa

Multivariate analysis

HR

Lower 95% CI

Upper 95% CI

P value*

HR

Lower 95% CI

Upper 95% CI

P value*

Age at CAR Tb

0.990

0.977

1.003

0.1

    

Sex (male)

1.19

0.85

1.65

0.3

    

CAR T construct (axi-cel)

1.47

0.87

2.50

0.2

    

ECOG ≥ 1

0.72

0.52

0.99

0.05

0.76

0.54

1.08

0.1

Lines of therapy prior to CAR Tb

1.028

0.872

1.084

0.6

    

Bridging therapy prior to CAR T

0.66

0.47

0.93

0.02*

0.98

0.67

1.44

0.9

Time from diagnosis to CAR T (months)b

1.001

0.999

1.004

0.3

    

ANCb

0.992

0.948

1.038

0.7

    

Hemoglobinb

1.17

1.07

1.28

<0.01*

1.029

0.920

1.150

0.6

Plateletsb

1.003

1.001

1.004

<0.01*

1.003

1.001

1.004

<0.01*

LDHb

0.999

0.998

0.999

<0.01*

0.999

0.998

0.999

0.01*

Albuminb

2.405

1.647

3.513

<0.01*

1.74

1.09

2.78

0.02*

Prophylactic G-CSFc

1.84

1.27

2.67

<0.01*

2.11

1.39

3.20

<0.01*

  1. *P < 0.05, indicating statistical significance in univariate or multivariate models, is denoted by asterisks.
  2. aVariables with P < 0.10 in Cox univariate proportional hazards model were included in the multivariate model.
  3. bContinuous hazard ratio (per unit change in regressor).
  4. cProphylactic G-CSF refers to exposure to G-CSF prior to CAR T cell infusion.
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