Table 5 Cox proportional hazards model for Grade ≥2 ICANS in lymphoma cohort.

From: Effect of granulocyte colony-stimulating factor on toxicities after CAR T cell therapy for lymphoma and myeloma

Variable

Univariate analysisa

Multivariate analysis

HR

Lower 95% CI

Upper 95% CI

P value*

HR

Lower 95% CI

Upper 95% CI

P value*

Age at CAR Tb

1.006

0.988

1.024

0.5

    

Sex (male)

0.81

0.50

1.31

0.4

    

CAR T construct (axi-cel)

2.59

1.04

6.44

0.04*

3.15

1.17

8.47

0.02*

ECOG ≥ 1

1.86

1.14

3.04

0.01*

1.45

0.87

2.41

0.2

Lines of therapy prior to CAR Tb

1.035

0.892

1.202

0.6

    

Bridging therapy prior to CAR T

0.96

0.59

1.57

0.9

    

Time from diagnosis to CAR T (months)b

0.997

0.991

1.002

0.2

    

ANCb

1.052

0.987

1.121

0.1

    

Hemoglobinb

0.781

0.685

0.891

<0.01*

0.897

0.764

1.054

0.2

Plateletsb

1.000

0.997

1.002

0.7

    

LDHb

1.001

1.001

1.002

<0.01*

1.001

1.000

1.002

0.08

Albuminb

0.388

0.256

0.588

<0.01*

0.673

0.395

1.146

0.1

Prophylactic G-CSFc

1.23

0.71

2.13

0.5

1.04

0.59

1.84

0.9

  1. *P < 0.05, indicating statistical significance in univariate or multivariate models, is denoted by asterisks.
  2. aVariables with P < 0.10 in Cox univariate proportional hazards model were included in the multivariate model. The variable of interest, prophylactic G-CSF, was included in the model to study its effect on the development of Grade ≥2 ICANS.
  3. bContinuous hazard ratio (per unit change in regressor).
  4. cProphylactic G-CSF refers to exposure to G-CSF prior to CAR T cell infusion.
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