Table 3 Multivariate Cox proportional hazards regression analyses.

From: Poor prognostic implications of myelodysplasia-related mutations in both older and younger patients with de novo AML

Variables

EFS

OS

HR

Lower

Upper

P value

HR

Lower

Upper

P value

Agea

1.011

1.006

1.016

<0.001

1.017

1.011

1.023

<0.001

WBC countsa (k/μL)

1.002

1.001

1.003

<0.001

1.002

1.001

1.003

<0.001

2017 ELN classificationc

Intermediate vs. favorable

2.022

1.643

2.489

<0.001

2.257

1.792

2.843

<0.001

Adverse vs. favorable

3.809

3.060

4.740

<0.001

4.297

3.384

5.455

<0.001

HSCT at first CRb

0.317

0.250

0.402

<0.001

0.408

0.317

0.524

<0.001

MDS-R mutations

1.225

1.009

1.488

0.040

1.239

1.005

1.526

0.045

  1. CR complete remission, ELN European LeukemiaNet, MDS-R myelodysplasia-related, WBC white blood cell.
  2. aContinuous variables.
  3. bHSCT at CR1 vs. HSCT at other disease statuses or without HSCT.
  4. cSince AML with myelodysplasia-related gene mutations belongs to the adverse category in the 2022 ELN risk classification, we used the 2017, instead of 2022, ELN risk classification as a covariate.
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