Table 4 Minimal Residual Disease (MRD) Positivity Value (Clone 1 – Log) by Baseline Disease Characteristics and IMWG Response Criteria at Day 100 Post-Autologous Stem Cell Transplant (ASCT).
CATEGORY | MEAN (SD) | MEDIAN | P-value |
|---|---|---|---|
GENDER | 0.531 | ||
Female | 4.0 (2.95) | 3.4 | |
Male | 4.3 (2.92) | 4.6 | |
MM Subtype | 0.731 | ||
IgA Kappa | 3.9 (2.74) | 3.3 | |
IgA Lambda | 4.4 (2.81) | 4.1 | |
IgD Lambda | 3.9 (NA) | 3.9 | |
IgG Kappa | 4.4 (2.93) | 4.7 | |
IgG Lambda | 4.7 (2.75) | 5.1 | |
IgM Kappa | 5.3 (NA) | 5.3 | |
Kappa Light Chain | 3.6 (3.27) | 3.3 | |
Lambda Light Chain | 3.6 (3.49) | 1.7 | |
Non-Secretory | 0.8 (5.32) | 0.8 | |
R-ISS Stage | 0.131 | ||
Stage I | 4.2 (2.73) | 4.7 | |
Stage II | 4.6 (3.16) | 4.4 | |
Stage III | 2.9 (2.81) | 2 | |
Genetic risk | 0.531 | ||
High Risk | 3.8 (2.61) | 3.3 | |
Standard Risk | 4.3 (3.01) | 4.5 | |
Modified genetic risk | 0.841 | ||
High Risk “Plus” | 4.3 (3.01) | 4.6 | |
Standard Risk | 4.2 (2.94) | 4.3 | |
Pet interpretation | 0.0021* | ||
Positive | 5.7 (2.58) | 5.8 | |
Negative | 3.7 (2.89) | 3.6 | |
IMWG Response criteria | <0.0011* | ||
sCR | 2.2 (2.16) | 1.9 | |
CR | 5.1 (2.70) | 5.3 | |
VGPR | 5.7 (2.14) | 5.7 | |
PR | 7.2 (1.94) | 7.4 | |
MR | 8.6 (NA) | 8.6 | |
PD | 7.5 (3.72) | 7.5 |
