Table 2 Frequency of medication usage by progression outcome.

From: Artificial intelligence-enabled screening strategy for drug repurposing in monoclonal gammopathy of undetermined significance

 

Progression (n = 404)

No progression (n = 11849)

P-value

Medication class

 Anticoagulant

16.20%

22.70%

P < 0.00001

 ACE inhibitor

31.30%

36.60%

P < 0.00001

 Beta blocker

31.60%

45.10%

P < 0.00001

 Myelodysplastic syndrome drug

5.80%

0.90%

P < 0.00001

 NSAID

18.00%

22.10%

P < 0.00001

 Proton-pump inhibitor

27.60%

43.10%

P < 0.00001

 Antiplatelet drug

48.40%

43.80%

P < 0.00001

 Estrogen supplement

1.80%

1.70%

P = 0.7

 Folic acid

15.50%

20.50%

P < 0.00001

 Aldosterone receptor antagonist

7.80%

10.90%

P < 0.00001

 Immunomodulator

4.30%

9.80%

P < 0.00001

 Loop diuretic

20.60%

28.80%

P < 0.00001

 Metformin

7.80%

11.30%

P < 0.00001

 Multivitamin

30.80%

42.10%

P < 0.00001

 Opioid

22.10%

34.30%

P < 0.00001

 Rituximab

1.50%

1.60%

P = 0.6

 Statin

35.30%

49.70%

P < 0.00001

 Corticosteroid

20.80%

30.20%

P < 0.00001

 Testosterone supplement

1.80%

2.10%

P = 0.2

 Thyroid replacement

15.00%

19.70%

P < 0.00001

 Vitamin D supplement

46.40%

49.60%

P < 0.001