Table 3 Model features and associated hazard ratios with confidence intervals.

From: Artificial intelligence-enabled screening strategy for drug repurposing in monoclonal gammopathy of undetermined significance

Model feature

Median HR

5th percentile HR

95th percentile HR

Patient characteristics

(statistically significant)

 Death from other cause

0.0541

0.0286

0.0788

 Chronic liver disease

0.472

0.214

0.821

 Chronic heart disease

0.484

0.323

0.75

 Solid organ transplant

0.577

0.217

0.983

 Body mass index

1.808

1.169

2.821

Disease characteristics

(statistically significant)

 Serum IgM level

0.519

0.303

0.834

 Hemoglobin

0.554

0.35

0.931

 IgG subtype

0.621

0.415

0.856

 Calcium

0.633

0.406

0.946

 IgM subtype

1.618

1.106

2.561

 IgA subtype

1.814

1.24

2.7

 Serum M-spike

4.931

2.908

10.245

Medications

(statistically significant)

 Multivitamin

0.495

0.345

0.706

 Immunosuppression

0.589

0.289

0.956

 Non-coronary NSAID

0.614

0.412

0.856

 Proton pump inhibitor

0.626

0.429

0.889

 Vitamin D supplementation

0.675

0.47

0.928

 Opioid

0.676

0.471

0.935

 Statin

0.682

0.48

0.973

 Beta blocker

0.742

0.521

0.972

Patient characteristics

(non-significant)

 Black race

0.497

0.194

1

 Diabetes

0.743

0.497

1.064

 Autoimmune disease

0.789

0.386

1.3

 White race

0.88

0.535

1.642

 History of bacteremia

1

0.802

1.345

 American Indian race

1

1

1

 Pacific Islander race

1

1

1

 Other race

1

1

1

 Asian race

1

0.965

9.281

 Race Unknown

1

1

1

 Chronic kidney disease

1.067

0.674

1.639

 Male

1.254

0.921

1.754

 Age at diagnosis

1.442

0.802

2.285

Disease characteristics

(non-significant)

 Serum IgA level

0.713

0.441

1.106

 Serum IgG level

0.768

0.463

1.384

 Serum albumin level

0.889

0.584

1.365

 Serum creatinine

0.972

0.587

1.622

 Beta 2 glycoprotein

1.035

0.612

1.986

 Serum kappa level

1.12

0.699

2.063

 Serum kappa/lambda ratio

1.4227

0.88

2.611

 Serum lambda level

1.504

0.88

2.611

Medications

(non-significant)

 Testosterone supplementation

0.673

0.223

1.295

 Thyroid supplementation

0.715

0.471

1.03

 Folic acid

0.747

0.502

1.048

 ACE inhibitor

0.782

0.54

1.105

 Metformin

0.848

0.488

1.296

 Rituximab

0.85

0.369

1

 Aldosterone antagnoist

0.915

0.554

1.303

 Estrogen supplementation

1

0.663

1.668

 Corticosteroid

1.014

0.678

1.412

 Therapeutic dose anticoagulant

1.073

0.759

1.429

 Antiplatelet medication

1.119

0.799

1.522

 Loop diuretic

1.299

0.926

1.801

 Myelodysplastic syndrome drug

1.858

0.722

5.174

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