Table 2 Clinical presentation of TMA.

From: Mutations in the alternative complement pathway in multiple myeloma patients with carfilzomib-induced thrombotic microangiopathy

Patient

Hgb (g/dL)

Platelet count (×109/L)

Cr (mg/dL)

Baseline Cr (mg/dL)

LDH (U/L)

Anuria/Oliguria

GI sx

New HTN at time of TMA diagnosis

TMA confirmed by renal biopsy

1

7.7

30

2.0

0.65

619

Y

N

Y

N

2

7.7

20

3.08

1.19

371

Y

N

Y

N

3

13

31

1.04

0.86

240

N

N

N

Y

4

7.9

10

11.66

0.8

2150

N

Y

N

N

5

12.3

190

2.40

0.74

451

Y

N

N

N

6

9.7

139

1.42

0.82

262

Y

N

Y

Y

7

9.0

10

0.92

0.81

635

Y

N

N

N

8

9.9

223

2.05

1.38

141

Y

N

Y

N

9

6.9

16

6.54

2.4

401

N

Y

N

N

10

10.5

23

4.63

1.3

2150

Y

N

N

Y

  1. The table shows pertinent laboratory values, signs and symptoms occurring at the time of TMA diagnosis. For specific patients, definitive histo-pathologic diagnosis of TMA was obtained through renal biopsy.
  2. Hgb hemoglobin, Cr creatinine, GI sx gastrointestinal symptoms, HTN hypertension, Y yes, N no.
  3. Normal range values: Hgb 14–17.5 g/dl (male) and 12–15.5 (female); Plt 140–400 × 109/L, LDH normal range: 135–225 U/L.
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