Table 1 Patient characteristics.

From: CD19/CD22 bispecific CAR-T cells for MRD-positive adult B cell acute lymphoblastic leukemia: a phase I clinical study

Baseline characteristics

All patients evaluable (N = 15)

First-line consolidation (N = 11)

Relapsed group (N = 4)

P

Median age, years (range)

51 (23–70)

45 (23–70)

54.5 (31–61)

0.447

Age ≥ 35 years, n (%)

10(66.7%)

7(63.6%)

3(75%)

0.68

Male, n (%)

6 (40%)

5 (45.5%)

1 (25%)

0.348

ECOG performance status score of 0–1, n (%)

15 (100%)

11 (100%)

4 (100%)

>0.99

Median time since diagnosis, months (range)

6.5 (1–41.5)

6.5 (3–18)

7 (1–41.5)

0.851

Median Cycle Number of chemotherapy, n (range)

4(3–8)

4(3–5)

3.5 (3–8)

0.949

Ph-positive

7(46.7%)

3(27.3%)

4(100%)

0.026

Disease burden

 Before lymphodepletion

  MRD ≥ 10–2

2(13.3%)

1(9.1%)

1(25%)

0.4

  MRD ≥ 10–3–<10–2

5(33.3%)

3(27.3%)

2(50%)

 

  MRD ≥ 10–4–<10–3

8(53.3%)

7(63.6%)

1(25%)

 

 Before infusion

  MRD ≥ 10–2

3(21.4%)

1(9.1%)

2(50%)

0.183

  MRD ≥ 10–3–<10–2

5(35.7%)

5(45.5%)

0

 

  MRD ≥ 10–4–<10–3

1(7.1%)

1(9.1%)

0

 

  MRD Negative

5(35.7%)

3(27.3%)

2(50%)

 

Follow-up time

15.5(2.5–33)

15.5(2.5–33)

15.25(10.5–20.5)

0.949