Fig. 3: TP53mut was enriched in complex karyotype (CK) and is associated with significantly poor outcome of CK t-MN. | Blood Cancer Journal

Fig. 3: TP53mut was enriched in complex karyotype (CK) and is associated with significantly poor outcome of CK t-MN.

From: TP53 mutation variant allele frequency of ≥10% is associated with poor prognosis in therapy-related myeloid neoplasms

Fig. 3: TP53mut was enriched in complex karyotype (CK) and is associated with significantly poor outcome of CK t-MN.The alternative text for this image may have been generated using AI.

A Frequency of TP53mut according to number of structural cytogenetic abnormalities; B High frequency of TP53mut in typical-CK compared to atypical-CK t-MN; C TP53mut cases were enriched for CK; D In the absence of CK, TP53mut were prevalent in cases with 5q loss compared to 7q loss (+, present; -; absent; +/-, present or absent). Loss of 5q was defined as monosomy 5 or del 5q, while loss of 7q was defined as monosomy 7 or del 7q; E CK is associated with significantly poor survival in t-MN; F TP53mut status further stratify CK with very poor outcome.

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