Fig. 2: Clinical response to anti-CD7 CAR-T cells.
From: Allogenic and autologous anti-CD7 CAR-T cell therapies in relapsed or refractory T-cell malignancies
A The clinical responses of patients’ BM and EMD post anti-CD7 CAR-T infusion are shown by swimmer plots. For patients without BM infiltration or EMD, striped bars are presented. PT patient, BM bone marrow, EMD extramedullary disease, CR complete remission, PR partial response, SD stable disease, PD progressive disease. * EMD did not existed during screening in patient 2 and she achieved MRD- CR after infusion. On the 140th post infusion, extramedullary recurrence occurred in the gastric wall, pelvic peritoneum and multiple lymph nodes detected by PET-CT. B Representative PET-CT images of patient 6 before and after anti-CD7 CAR-T cells infusion. As is shown in PET-CT, patient 6 had lesions in nasopharynx and left clavicle. The patient achieved extramedullary complete remission at day 30 post infusion. C Images of patient 1 before and after anti-CD7 CAR-T cells infusion. Patient 1 had diffuse lesions over the body, especially on his elbows and right knee (left), and achieved remarkable remission with a small phyma on the right knee on Day 65.
