Fig. 4: Serum biomarkers in peripheral blood after CAR-T cell infusions.
From: Allogenic and autologous anti-CD7 CAR-T cell therapies in relapsed or refractory T-cell malignancies
A A heatmap of biomarkers. Each row is a biomarker, and each column is a time point. At each time point, the color patches from left to right represent patient 1–10, respectively. B Kinetics of IL-6, IL-10 and IFN -γ in peripheral in individual patients measured by cytometric bead array. Pronounced increases of these cytokines were detected in patients 2, 5, 7, 8 and 9, which were overlapped with grade 1 or 2 cytokine release syndrome and precede the peak of CAR-T cell expansion.
