Table 2 Adverse events within a month post infusion.
From: Allogenic and autologous anti-CD7 CAR-T cell therapies in relapsed or refractory T-cell malignancies
Adverse events | Grade 1 | Grade 2 | Grade 3 | Grade 4 | Total patients |
|---|---|---|---|---|---|
CRS | |||||
Total score | 3 (30) | 4 (40) | 1 (10) | 0 | 8 (80) |
Fever | 3 (30) | 4 (40) | 1 (10) | 0 | 7 (70) |
Hypoxia | 0 | 3 (30) | 1 (10) | 0 | 4 (40) |
Hypotension | 0 | 2 (20) | 1 (10) | 0 | 3 (30) |
ICANS | |||||
Total score | 0 | 0 | 0 | 0 | 0 |
GVHD | |||||
Total score | 1 (10) | 1 (10) | 0 | 0 | 2 (20) |
Skin | 1 (10) | 1 (10) | 0 | 0 | 2 (20) |
Intestinal | 0 | 1 (10) | 0 | 0 | 1 (10) |
Liver | 0 | 0 | 0 | 0 | |
Hematological Event | |||||
Anemia | 1 (10) | 0 | 3 (30) | 0 | 4 (40) |
Thrombocytopenia | 2 (20) | 1 (10) | 1 (10) | 5 (50) | 4 (40) |
Leukopenia | 0 | 0 | 0 | 9 (90) | 9 (90) |
Neutropenia | 0 | 0 | 0 | 9 (90) | 9 (90) |
Lymphocytopenia | 0 | 0 | 0 | 9 (90) | 9 (90) |
Infection | |||||
Total scores | 0 | 0 | 5 (50) | 0 | 4 (40) |
Virus | 0 | 0 | 1 (10) | 0 | 1 (10) |
Bacteria | 0 | 0 | 3 (30) | 0 | 3 (30) |
Fungus | 0 | 0 | 1 (10) | 0 | 1 (10) |
Others | |||||
Hypofibrinogenemia | 5 (50) | 0 | 0 | 0 | 5 (50) |
Capillary leak syndrome | 2 (20) | 0 | 0 | 0 | 2 (20) |
HLH | 0 | 0 | 1 (10) | 1 (10) | 2 (20) |
