Table 1 Characteristics of MDS patients and univariate and multivariate analysis for overall survival (OS) and time to progression (TTP).
Parameters | Median (Range)a, N (%)b | TTP Univariate analysis P-value | TTP Univariate analysis HR; 95%CI | TTP Multivariate analysis P-valuec | TTP Multivariate analysis HR; 95%CI | OS Univariate analysis P-value | OS Univariate analysis HR; 95%CI | OS Multivariate analysis P-valuec | OS Multivariate analysis HR; 95%CI |
|---|---|---|---|---|---|---|---|---|---|
Age | |||||||||
Median (Range) | 73 (20–89) | 0.389 | 1.146 (0.840–1.565) per every 10 years >72 | 0.383 | 1.194 (0.801–1.780) per every 10 years >72 | ||||
Sex | |||||||||
Males | 72 (68.6) | 0.071 | 1.898 (0.947–3.802) for males | 0.184 | 1.761 (0.764–4.065) for males | ||||
Females | 33 (31.4) | ||||||||
Hb | |||||||||
Median (Range) | 9.7 (7.0–15.5) | 0.041 | 0.835 (0.702–0.993) for every unit >10 | 0.040 | 0.795 (0.639–0.989) for every unit >10 | ||||
N/A | 1 | ||||||||
ANC (x1000) | |||||||||
Median (Range) | 2.0 (0.0–19.7) | 0.020 | 1.040 (1.006–1.075) for every unit >4 | 0.123 | 1.036 (0.990–1.084) for every unit >4 | ||||
N/A | 1 | ||||||||
PLT (x1000) | |||||||||
Median (Range) | 148 (8–770) | 0.159 | 0.836 (0.651–1.073) for every 100 units >165 | 0.201 | 0.814 (0.595–1.115) for every 100 units >165 | ||||
N/A | 1 | ||||||||
BM blasts | |||||||||
Median (Range) | 3.0 (0.0–86.0) | 0.005 | 1.034 (1.010–1.058) for every unit >7 | 0.001 | 1.041 (1.017–1.066) for every unit >7 | 0.001 | 1.042 (1.017–1.068) for every unit >7 | <0.001 | 1.054 (1.027–1.081) for every unit >7 |
N/A | 1 | ||||||||
Cytogenetics (IPSS-R) | |||||||||
Very good | 12 (12.0) | 0.040 | 1.871 (1.028–3.407) for Cytogenetics IPSS-R risk categories Intermediate/High/Very High | 0.209 | 1.602 (0.768–3.341) for Cytogenetics IPSS-R risk categories Intermediate/High/Very High | ||||
Good | 63 (63.0) | ||||||||
Intremediate | 15 (15.0) | ||||||||
Poor | 5 (5.0) | ||||||||
Very poor | 5 (5.0) | ||||||||
N/A | 5 | ||||||||
Mutations (total) | |||||||||
Median (Range) | 1.0 (0.0–6.0) | 0.042 | 1.388 (1.012–1.904) for every unit >1 | Ν/Α | Ν/Α | 0.032 | 1.042 (1.017–1.068) for every unit >1 | Ν/Α | Ν/Α |
N/A | 74 | ||||||||
MDS-CI risk category | |||||||||
Low | 70 (68.6) | 0.442 | 0.794 (0.442–1.429) for every risk category higher than “Low” | 0.790 | 1.079 (0.617–1.889) for every risk category higher than “Low” | ||||
Intermediate | 25 (24.5) | ||||||||
High | 7 (6.9) | ||||||||
N/A | 3 | ||||||||
Transfusion dependence | |||||||||
YES | 70 (30.0) | ||||||||
NO | 30 (30.0) | 0.351 | 1.344 (0.722–2.504) for transfusion dependence | 0.415 | 1.361 (0.649–2.584) for transfusion dependence | ||||
N/A | 5 | ||||||||
CRP (mg/l) | |||||||||
Median (Range) | 4.1 (0.0–128.0) | 0.030 | 1.109 (1.010–1.218) for every ten units >15 | 0.003 | 1.158 (1.050–1.278) for every ten units >15 | ||||
N/A | 2 | ||||||||
Troponin (ng/l) | |||||||||
Median (Range) | 14.0 (0.0–193.0) | 0.940 | 0.993 (0.833–1.184) for every ten units >20 | 0.374 | 1.071 (0.921–1.245) for every ten units >20 | ||||
N/A | 1 | ||||||||
GDF-15 (ng/l) | |||||||||
Median (Range) | 3184 (444–32,043) | 0.011 | 1.062 (1.014–1.112) for every 1000 units >5500 | 0.017 | 1.063 (1.011–1.118) for every 1000 units >5500 | 0.010 | 1.075 (1.015–1.135) for every 1000 units >5500 | 0.015 | 1.080 (1.015–1.149) for every 1000 units >5500 |
N/A | 1 | ||||||||
NT-proBNP (ng/l) | |||||||||
Median (Range) | 41.6 (2.1–1614) | 0.006 | 1.201 (1.055–1.368) for every 100 units >110 | 0.007 | 1.207 (1.052–1.384) for every 100 units >110 | 0.001 | 1.246 (1.099–1.412) for every 100 units >115 | 0.001 | 1.270 (1.107–1.457) for every 100 units >110 |
N/A | 1 | ||||||||
