Fig. 1: Mapping of ASXL1 mutations.
From: A reappraisal of ASXL1 mutation sites and the cohesin-binding motif in myeloid disease
A Lollipop plot of ASXL1 mutations by codon sites in all myeloid neoplasms (n = 1414). B Frequencies of ASXL1c.1934dupG and ASXL1other co-mutation with individual genes by phenotype (genes mutated in ≥5% of cases are shown). Gene names with frequency differences with a p-value < 0.05 are shown. ASXL1 Ensembl gene IDENSG00000171456.12; Ensembl transcript ENST00000375687.4 HARE-HTH HB1, ASXL, restriction endonuclease helix-turn-helix domain (codons 11–82), ASXH ASX homology domain (codons 237–361), Cohesin cohesin-binding motif (codons 401–587), Exon 13 codons 573–1541, PHD plant homeodomain zinc finger (codons 1500–39).
