Table 4 A: Multivariate logistic regression analysis results (association with severity). B: Multivariate Cox regression analysis results (association with survival).

From: Sample average treatment effect on the treated (SATT) analysis using counterfactual explanation identifies BMT and SARS-CoV-2 vaccination as protective risk factors associated with COVID-19 severity and survival in patients with multiple myeloma

A

 

Unadjusted analysis

Adjusted analysis

 

Odds Ratio

95% CI

P-value

Adjusted odds ratio

Pr(>|z | )

 
 

Age

1.033

1.03

1.04

 

1.031

1.09E-11

***

Sex

MALE

1.092

0.94

1.27

2.57E-01

0.891

2.35E-01

 

COVID_Vaccination

Vaccinated

0.356

0.29

0.44

<2.00e-16

0.283

<2.00e-16

***

BMI

Obese

1.075

0.84

1.37

5.61E-01

0.801

1.52E-01

 
 

Overweight

1.068

0.84

1.37

6.00E-01

1.004

9.78E-01

 
 

Underweight

2.221

1.31

3.78

3.25E-03

1.313

4.04E-01

 

Race

Black

1.362

0.66

2.80

4.02E-01

1.496

3.11E-01

 
 

Asian

0.846

0.39

1.82

6.69E-01

1.321

5.16E-01

 
 

Pacific_Islander

0.779

0.37

1.63

5.08E-01

1.787

1.57E-01

 

Smoking_status

Smoker

0.858

0.73

1.02

7.42E-02

0.804

5.30E-02

.

CCI_Level

MODERATE

1.418

1.12

1.79

3.38E-03

1.345

6.03E-02

.

 

SEVERE

2.793

2.30

3.39

<2.00e-16

1.775

9.34E-04

***

ISS_staging

Moderate_Severe

1.342

1.07

1.68

1.03E-02

1.516

4.14E-03

**

Medical history

Pulmonary

2.267

1.92

2.68

<2.00e-16

1.528

1.43E-04

***

 

Hypertension

1.901

1.62

2.23

3.11E-15

0.922

4.93E-01

 
 

PVD

1.784

1.45

2.19

3.00E-08

1.030

8.26E-01

 
 

Diabetes

2.081

1.78

2.44

<2.00e-16

1.060

6.02E-01

 
 

Renal

2.391

2.05

2.79

<2.00e-16

1.537

3.25E-04

***

Treatment

IMiDs

1.046

0.87

1.25

6.28E-01

1.437

2.81E-03

**

 

PI

1.000

0.80

1.26

9.98E-01

1.503

1.07E-02

*

 

BMT

0.448

0.37

0.54

4.44E-16

0.790

6.68E-02

.

 

Daratumumab

0.955

0.73

1.26

7.43E-01

1.090

6.37E-01

 
 

Dexamethasone

0.477

0.06

4.05

4.97E-01

2.231

5.78E-05

***

B

  

Adjusted Hazards Ratio (coef)

lower 0.95

upper 0.95

Pr(>|z|)

 

Age

 

1.040

1.02

1.06

3.98E-07

***

Sex

MALE

0.793

0.57

1.09

1.58E-01

 

COVID vaccination

Vaccinated

0.302

0.19

0.47

1.02E-07

***

BMI

Obese

1.045

0.67

1.64

8.48E-01

 
 

Overweight

1.287

0.84

1.97

2.44E-01

 
 

Underweight

0.808

0.28

2.31

6.90E-01

 

Race

Black

2.630

0.36

19.21

3.41E-01

 
 

Asian

2.192

0.27

17.72

4.62E-01

 
 

Pacific_Islander

2.847

0.38

21.24

3.08E-01

 

Smoking status

Smoker

0.918

0.65

1.30

6.27E-01

 

CCI Level

MODERATE

3.340

1.68

6.65

6.05E-04

***

 

SEVERE

5.138

2.55

10.36

4.84E-06

***

ISS staging

Moderate_Severe

1.549

0.98

2.45

6.22E-02

.

Medical history

Pulmonary

1.009

0.71

1.43

9.62E-01

 
 

Hypertension

0.961

0.64

1.45

8.49E-01

 
 

PVD

1.619

1.12

2.34

1.05E-02

*

 

Diabetes

0.737

0.52

1.04

8.29E-02

.

 

Renal

1.080

0.75

1.55

6.80E-01

 

Treatment

IMiDs

1.257

0.87

1.82

2.28E-01

 
 

PI

1.623

1.06

2.48

2.46E-02

*

 

BMT

0.653

0.42

1

5.49E-02

.

 

Daratumumab

1.291

0.80

2.09

2.97E-01

 
Back to article page