Table 1 Patient characteristics and analysis of prognostic factors.
Diagnostic variable | Univariate analysis | Cox-regression model | ||||
|---|---|---|---|---|---|---|
Patients (n = 119) | Events at 5 years (n = 61) | 5-year EFS (95% CI) | p-value (Log-rank) | Estimated hazard ratio (95% CI) | p-value (Wald test) | |
KMT2A status | ||||||
Germline | 38 (31.9%) | 10 (16.4%) | 73% (61–89) | <0.01 | 1 | |
Rearranged | 69 (58.0%) | 45 (73.8%) | 33% (23–46) | 2.29 (1.08–4.88) | 0.03 | |
Unknown | 12 (10.1%) | 6 (9.8%) | ||||
Sex | ||||||
Female | 68 (57.1%) | 28 (45.9%) | 58% (48–71) | <0.01 | 1 | |
Male | 51 (42.9%) | 33 (54.1%) | 32% (21–48) | 2.40 (1.35–4.26) | <0.01 | |
Age | ||||||
≥6 months | 70 (58.8%) | 26 (42.6%) | 62% (51–75) | <0.01 | 1 | |
<6 months | 49 (41.2%) | 35 (57.4%) | 26% (16–42) | 2.17 (1.12–4.19) | 0.02 | |
CNS status | ||||||
Negative | 73 (61.3%) | 30 (49.2%) | 57% (47–70) | <0.01 | 1 | |
Positive | 40 (33.6%) | 27 (44.3%) | 31% (19–49) | 1.13 (0.61–2.08) | 0.71 | |
Unknown | 6 (5.0%) | 4 (6.6%) | ||||
White blood cell count | ||||||
<100 | 53 (44.5%) | 18 (29.5%) | 65% (53–79) | <0.01 | 1 | |
≥100 | 60 (50.4%) | 39 (63.9%) | 34% (24–48) | 1.88 (0.98–3.60) | 0.06 | |
Unknown | 6 (5.0%) | 4 (6.6%) | ||||
CD10 status | ||||||
Positive | 40 (33.6%) | 14 (23.0%) | 64% (50–81) | 0.01 | 1 | |
Negative | 76 (63.9%) | 45 (73.8%) | 39% (30–52) | 1.04 (0.51–2.13) | 0.92 | |
Unknown | 3 (2.5%) | 2 (3.3%) | ||||
