Table 3 Adverse events during consolidation treatment, n (%).

From: Long-term outcome of children with acute promyelocytic leukemia: a randomized study of oral versus intravenous arsenic by SCCLG-APL group

 

Total

N = 175

ATO

N = 85

RIF

N = 90

p

Infection/FUO

60 (34.3)

36 (42.4)

24 (26.7)

0.029

PCT

48 (27.4)

29 (34.1)

19 (21.1)

0.063

Coagulopathy events

 Hemorrhage

7 (4.0)

5 (5.9)

2 (2.2)

0.267

 Thrombosis

2 (1.1)

1 (1.2)

1 (1.1)

1.000

Liver

 Grade 1–2

5 (2.9)

2 (2.4)

3 (3.3)

1.000

 Grade 3–4

0 (0)

0 (0)

0 (0)

-

Cardiaca

 Grade 1–2

3 (1.7)

3 (3.5)

0 (0)

0.112

 Grade 3–4

1 (0.6)

1 (1.2)

0 (0)

0.486

Gastrointestinal dysfunction

 Grade 1–2

27 (15.4)

11 (12.9)

16 (17.8)

0.376

 Grade 3–4

0 (0)

0 (0)

0 (0)

-

 Rash

2 (1.1)

1 (1.2)

1 (3.3)

1.000

  1. FUO fever of unknown origin, PCT pseudotumor cerebri.
  2. aThe difference in the total incidence of cardiac events (grade 1–4) between the ATO and RIF groups was close to being significant (p = 0.054).