Table 1 Fixed and time-dependent risk factors for death prediction in 891 ET patients.

From: Prediction models for essential thrombocythemia from two longitudinal studies involving 2000 patients

Covariates

HR

p

95% CI

Fixed variables

Male sex

0.86

0.531

0.55–1.36

Age > 60 years

5.53

0.000

3.44–8.90

JAK2V617F

1.30

0.560

0.54–3.14

CV risk factors

3.04

0.000

1.88–4.92

Previous arterial thrombosis

2.09

0.002

1.31–3.36

Previous venous thrombosis

1.32

0.362

0.72–2.43

Time-dependent variables

Arterial thrombosis

2.60

0.002

1.44–4.70

Venous thrombosis

1.23

0.669

0.47–3.25

Evolution to Myelofibrosis

4.35

0.002

1.69–11.20

Evolution to Blast phase

38.58

0.000

15.84–93.95

  1. Cox regression model adjusted for variables known at ET diagnosis (fixed effects) and time-dependent variables for events occurring during follow-up (variable effects) to identify risk factors for mortality. In bold statistically significant (i.e., p < 0.05) variables.
  2. HR hazard ratio, CI confidence interval, CV cardiovascular.
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