Table 4 Cole’s co-efficient values for co-occurrence between precursor diagnoses.

Organ system 1	Precursor diagnosis 1	Organ system 2	Precursor diagnosis 2	Cole’s Co-efficient	p value
Gastrointestinal	Dysphagia	Other	Macroglossia	0.86	0.002
Neurologic	Autonomic neuropathy	Cardiac	Dyspnea	0.76	0.009
Cardiac	Cardiomyopathy	Cardiac	Heart failure	0.74	<0.001
Renal	Nephrotic syndrome	Renal	Renal disease	0.73	<0.001
Renal	Nephritic syndrome	Renal	Renal disease	0.68	<0.001
Neurologic	Neuropathy	Other	Purpura	0.68	<0.001
Renal	Acute kidney injury	Renal	Nephritic syndrome	0.68	<0.001
Cardiac	Cardiomegaly	Cardiac	Dyspnea	0.68	<0.001
Neurologic	Autonomic neuropathy	Other	Fatigue	0.68	0.004
Cardiac	Dyspnea	Cardiac	Heart failure	0.67	<0.001
Other	Fatigue	Other	Purpura	0.65	<0.001
Cardiac	Dyspnea	Multi-organ	Pleural effusion	0.65	<0.001
Renal	Acute kidney injury	Renal	Renal disease	0.65	<0.001
Neurologic	Autonomic neuropathy	Multi-organ	Orthostatic hypotension	0.64	<0.001
Renal	Nephritic syndrome	Renal	Proteinura	0.63	<0.001
Neurologic	Autonomic neuropathy	Multi-organ	Syncope	0.62	<0.001
Cardiac	Cardiomegaly	Cardiac	Heart failure	0.62	<0.001
Multi-organ	Ascites	Multi-organ	Edema	0.61	<0.001
Gastrointestinal	Altered bowels	Gastrointestinal	Nausea/vomiting	0.60	<0.001
Gastrointestinal	Altered bowels	Neurologic	Autonomic neuropathy	0.60	0.006

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