Table 1 Clinical and pathological characteristics of included patients.

From: Indolent nodal T follicular helper cell lymphomas—A case series

Case number

Sex/Age at diagnosis

Ann Arbor Stage

Pattern

T-cell phenotype or TFH phenotype

Epstein-Barr virus-encoded RNA (EBER)

Management

Follow-up

Status at last follow-up

Case 1

Male/ 64

I

AITL patterns 1 & 2

CD4 + , PD1 + , ICOS+

Negative

Surgical excision of single site of involvement and observation

5 years

Alive

Case 2

Male/ 69

II

AITL pattern 1

CD4 + , PD1 + , ICOS+

Negative

Observation

5 years

Alive

Case 3

Female/ 70

I

AITL pattern 1

CD4 + , CD10 + , PD1 + , ICOS+

Scattered positive

Excisional LN biopsy of single site of disease

5 years

Alive

Case 4

Female / 72

I

AITL pattern 1

PD1 + , ICOS+

EBER+ in large B cell immunoblasts

Observation

3 years

Alive

Case 5

Female / 67

III

AITL pattern 1

CD4+ PD1 + ICOS +

Positive

Observation

6 years

Alive

Case 6

Female / 42

III

AITL pattern 1

CD4+ PD1 + ICOS +

Positive

Observation

5 years

Alive

Case 7

Female / 52

II

AITL patterns 1 & 2

ICOS+ PD1+

Positive

Prednisolone and paracetamol

5 years

Alive

Case 8

Female / 74

IV

AITL pattern 1

CD4 + CD5-a

Positive

Prednisolone for concomitant diagnosis of ILD

6 years

Deceased

Case 9

Female / 78

II

AITL pattern 3

CD4 CD10+ BCL6+ PD1+

Positive

Prednisolone

22 months

Deceased

  1. aCD4 + T-cells with CD5 loss are present in peripheral areas of germinal centers in keeping with a neoplastic Tfh population. Prominent high endothelial venules and presence of focal areas of follicular dendritic cell expansion are seen.