Fig. 2: Neutrophil-to-lymphocyte ratio (NLR) and the risk of total thrombosis, MF evolution and death.

A Generalized additive proportional hazard models (GAM) for the prediction of total thrombosis, MF evolution and death according to Neutrophil-to-lymphocyte ratio (NLR): the effect of NLR is analyzed on a continuous scale by GAM smooth function with cubic splines. Hazard-ratio estimates (solid line) along with their 95% confidence intervals (gray areas) are plotted in logarithmic scale. B Multivariable Cox proportional hazards regression model with fixed and time-dependent variables showing the significant independent effect of NLR on the risk of death.