Fig. 2: Cellular hierarchy composition and its association with drug response, cell cycle related gene set enrichment score, and patient survival.

A Distribution of cellular hierarchy composition (GMP, Intermediate, Mature, and Primitive) across non-CK, TP53^wt CK, and TP53^mut CK groups. B Pearson correlation between the proportion of each cell type and drug sensitivity (-AUC) in the BeatAML cohort, with colors representing the direction of the correlation. Only significant correlations (P < 0.05) are depicted. C Comparison of AUC values for elesclomol and D enrichment scores of three cell cycle-related gene sets between primitive and other cell types in the TP53^mut CK group. Detailed cell types within the ‘Others’ category is shown for the hall mark mitotic spindle gene set. E Overall survival outcomes of AML hierarchy subtypes in the TP53^mut CK group. Differences in survival outcomes between the subtypes were assessed using the log-rank test.