Fig. 1: Consensus clusters of gene expression data from Set 1. | Blood Cancer Journal

Fig. 1: Consensus clusters of gene expression data from Set 1.

From: Transcriptomic clustering of chronic lymphocytic leukemia: molecular subtypes based on Bruton’s tyrosine kinase expression levels

Fig. 1

Hierarchical clustering of normalized gene expression data revealed two distinct groups associated with BTK expression (A). The hierarchical clustering was repeated 10,000 times, taking a subset (80%) of samples and genes for every iteration to generate robust consensus groups. Consensus clustering was performed on the normalized expression data using 5000 genes with the highest median absolution deviation (B). The consensus clusters (k = 2) are significantly associated with BTK mRNA expression (C, BTK subtypes). There is significant difference in these BTK subtype’s probability of remaining untreated (progression-free) within this CLL cohort (D).

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