Fig. 6: BTK transcript correlated with BTK protein levels and BTK subtypes are associated with chemokine levels and disease burden. | Blood Cancer Journal

Fig. 6: BTK transcript correlated with BTK protein levels and BTK subtypes are associated with chemokine levels and disease burden.

From: Transcriptomic clustering of chronic lymphocytic leukemia: molecular subtypes based on Bruton’s tyrosine kinase expression levels

Fig. 6

CLL lymphocytes from peripheral blood of 25 patients were isolated to measure basal levels of BTK protein. BTK protein levels (IHC) between BTK-Low and BTK-High subtypes are statistically significant (A). Spearman correlation is used to assess the association between BTK Protein and BTK mRNA and values are listed on the graph (B). Data points from BTK-Low are presented as turquoise blue symbols while data points from BTK-High are represented as red symbols. Plasma CCL3 (Mip-1α) and CCL4 (Mip-1β) levels were quantitated using enzyme-linked immunosorbent assay (ELISA). Their levels were significantly associated with BTK subtypes (C, D). White Blood Cell (WBC) counts in the peripheral blood were also quantified for this cohort. Spearman correlation is used to assess the association between BTK Protein and WBC counts (E). WBC counts are significantly different between the BTK subtypes (F).

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