Fig. 1: Evolution of hemogram parameters, family history, and bone marrow characteristics of the propositus. | Blood Cancer Journal

Fig. 1: Evolution of hemogram parameters, family history, and bone marrow characteristics of the propositus.

From: CALRins5-mediated clonal hematopoiesis causes severe hemolytic anemia in a female PGK1Ser320Asn carrier

Fig. 1

A Hemoglobin (g/dL), platelets (103/µL), LDH (U/L), and bilirubin (mg/dL) levels of the propositus are shown over a 6-year period (June/2017–February/2023). The time of diagnosis of essential thrombocythemia (ET) is indicated. B Pedigree showing the presence of the PGK1 p.Ser320Asn variant in family members. C Bone marrow aspirate of the propositus (II.1) at admission showing marked hypercellularity with hyperplasia of megakaryocytes (top), characteristically enlarged, mature, with hyperlobulated nuclei (middle), along with erythroid hyperplasia (bottom). The dashed line indicates an enriched zone in megakaryocytes within the cell clump.

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